This study aimed to assess the quality and suitability of water sources for irrigation in Sohag area. A total number of 61 different water samples were collected from various sources which were representative of the study area. The water samples were analyzed in terms of properties pH, EC_w, soluble cations, and anions. Water samples were alkaline (pH above 7.00), EC_w ranged between very low (0.21 dS.m^-1) and very high (5.62 dS.m^-1). Soluble sodium was the dominant cation followed by calcium, magnesium, and potassium, respectively. Regarding soluble anions, chloride was dominant and followed by sulphates and bicarbonates. The data of water analysis have been put into several indices for assessing water suitability for irrigation such as electrical conductivity (EC_w), total dissolved salts (TDS), residual sodium carbonates (RSC), sodium adsorption ratio (SAR), sodium percentage (SP), permeability index (PI), Kelly ratio (KR), and magnesium hazard (MH). The most prominent results was that the water used for irrigation in sites of Elmonshah, Sohag, Akhmim, and El-Maraghah were not suitable for irrigation, while the water from other sources was of sufficient quality and suitability for irrigation. Water quality maps were produced using GIS. The results of this study along with spatial maps can be used as a guide for decision-makers in achieving better planning for water management and optimal utilization.