Background: Upper gastrointestinal bleeding (UGIB) is common cause of emergency GI admission. UGIB could accompany with adverse events if not treated timely. Different scoring systems have been suggested for diagnosing these patients, Aim and objectives; to compare the predictive value of the AIMS65 with the Glasgow Blatchford Scale (GBS) score for UGIB patients, Subjects and methods; A cross sectional study, carried out on patients presented with UGIB in Aswan University Hospital, from July 2020 to December 2020. Seventy-three patients were enrolled. Result: Mean age was 43.45 years. Majority (69.6%) of patients was males. Forty-seven (64.4%) patients presented with melena. It was found that AIMS65 and GBS score were significantly higher among patients admitted to intensive care unit (ICU) and died. AIMS65 had 60% sensitivity and 64.15% specificity for prediction of ICU's and 55.56% sensitivity and 59.38% specificity for prediction of mortality while GBS had 55% sensitivity and 90.57% specificity for prediction of ICU's and 77.78% sensitivity and 93.75% specificity for prediction of mortality Conclusion; GBS was superior to AIMS65 score in prediction of ICU admission and mortality.