The effect of sliding conditions, typically, applied load, sliding speed and volume fraction of nano Boron nitride (BN)particles on coefficient of friction and wear rate of epoxy nanocomposites was evaluated and optimized. Experiments were carried out using pin on disc machine on cylindrical specimens of Bn/epoxy. The analysis and optimization via analysis of variance (ANOVA) based on Taguchi L27 orthogonal array design of experiments technique (DOE) were carried out to determine the most influential parameter on wear rate and coefficient of friction. The results of ANOVA analysis showed that parameters volume fraction of BN, sliding speed and load were significant factors on coefficient of friction and wear rate. The sequence of importance of process parameters on multi-responses by grey relation analysis (GRA) were BN%> speed %> applied load.