Multi-walled carbon nano tubes (MWCNTs) was used as a high-density polyethylene reinforcement material in epoxy-based nano composites. The effect of sliding conditions typically; applied load, sliding speed and volume fraction of the MWCNTs on coefficient of friction and wear rate was evaluated and optimized. Cylindrical specimens having of 0.5, 1 and 1.5% volume fraction of MWCNTs were worn using a pin on disc machine. The analysis and optimization was carried out by analysis of variance (ANOVA). L27 orthogonal array design of experiments(DOE) technique were used to determine the most influential parameter on wear rate and coefficient of friction. The results by ANOVA analysis with Taguchi (DOE) showed that parameters; volume fraction, speed and load were significant factors on coefficient of friction and wear rate. The sequence of importance of process parameters on multi-responses by (RSM) were applied the load followed by volume fraction, and finally the sliding speed.