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227806

Intuition on virology, epidemiology, pathogenesis, and control of COVID-19

Article

Last updated: 23 Jan 2023

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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of coronavirus disease (COVID-19), and represents the causative agent of a potentially systemic disease that has drawn a global attention. Based on the study of large number of infected people who were exposed to the bat animal market in Wuhan city, China, they suggested that the disease caused by SARS-CoV-2 (i.e., COVID-19) is likely to be associated with zoonotic transmission. The disease was declared as pandemic by the World Health Organization (WHO) on 11th of March, 2020. The clinical and genetic characteristics of SARS-CoV-2 support a similar pathogenesis pattern with Severe acute respiratory syndrome (SARS) and Middle east respiratory syndrome (MERS-CoV). The infection is mainly transmitted from person to person through respiratory droplets generated during the course of coughing, sneezing and talking. Extensive measures to reduce the person to person transmission of COVID-19 have been implemented to control the current outbreak. Special attention and efforts reduce the transmission should be applied on the susceptible population including the children, health care providers and elderly people. Several control and preventive measures including; following hand hygiene, using face mask, avoiding person to person contact etc. are recommended to prevent the spread of this virus. To diagnose the viral infection, several methods have been established and recommended including the Real-time polymerase chain reaction (RT-PCR), serological diagnosis, imaging technology etc. Up to the 31th August, 2020, there is no specific therapeutics or vaccines to control this viral infection. So, COVID-19 is posing a great threat for the global public health. The aims of this review were to highlight the current status of COVID-19 worldwide, and to give short notes about its possible prevention and treatment.

DOI

10.21608/nrmj.2020.118446

Keywords

COVID-19, SARS-CoV, MERS-CoV, Acute respiratory distress syndrome (ARDS), Therapeutics

Authors

First Name

Gehendra

Last Name

Adhikari

MiddleName

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Affiliation

Department of Microbiology, Tri-Chandra Multiple Campus (Affiliated to Tribhuvan University), Ghantaghar, Kathmandu, Nepal

Email

gehendra2071@gmail.com

City

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Orcid

0000-0002-6831-3017

Volume

4

Article Issue

5

Related Issue

32643

Issue Date

2020-10-01

Receive Date

2020-09-13

Publish Date

2020-10-01

Page Start

955

Page End

967

Print ISSN

2537-0286

Online ISSN

2537-0294

Link

https://nrmj.journals.ekb.eg/article_227806.html

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https://nrmj.journals.ekb.eg/service?article_code=227806

Order

227,806

Type

Review Article

Type Code

2,338

Publication Type

Journal

Publication Title

Novel Research in Microbiology Journal

Publication Link

https://nrmj.journals.ekb.eg/

MainTitle

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Details

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Article

Created At

23 Jan 2023