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227592

In vitro inhibitory potential of two synthesized fatty amides derivatives against some microbial pathogens

Article

Last updated: 05 Jan 2025

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Abstract

In the present study, two amide derivatives with long chains; N-cyclohexyloctamide 1 and N-Phenyldodecanamide (dodecanilide) 2 were synthesized. They were tested in vitro for a wide array of antimicrobial activities against; two Gram positive bacteria (Bacillus subtilis, Staphylococcus aureus), four Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella enteric), and three fungi (Aspergillus carbonarius, Mucor ramannianus, Candida albicans), to evaluate their potential use as antimicrobial agents. Zones of inhibition of these compounds were determined by disc diffusion assay. Results revealed high antimicrobial activities of the two amides. The new fatty N-cyclohexyloctamide 1 showed significant antimicrobial activity against S. aureus and A. carbonarius, and was more active against C. albicans than synthesized fatty anilide 2, as it caused higher zones of inhibition. On the other hand, the fatty anilide 2 demonstrated high antibacterial activity against P. aeruginosa, and was more active against S. enteric than substituted fatty amide 1. On the basis of these obtained results, it could be assumed that fatty amide derivatives may be used as components of disinfectants, and may be possible sources of new drugs effective against various infectious diseases.

DOI

10.21608/nrmj.2019.28114

Keywords

Amide derivatives, Synthesis, antimicrobial activity, Disk diffusion assay

Authors

First Name

Fatiha

Last Name

Malki

MiddleName

-

Affiliation

Laboratoire De Recherche Sur Les Produits Bioactifs Et Valorisation De La Biomasse, Ecole Normale Supérieure, 16308,BP 92, Kouba, Algiers, Algeria

Email

malki_fatiha76@yahoo.fr

City

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Orcid

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First Name

Abdelkader

Last Name

Touati

MiddleName

-

Affiliation

Laboratoire De Recherche Sur Les Produits Bioactifs Et Valorisation De La Biomasse, Ecole Normale Supérieure, 16308,BP 92, Kouba, Algiers, Algeria

Email

-

City

-

Orcid

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Volume

3

Article Issue

1

Related Issue

32619

Issue Date

2019-02-01

Receive Date

2019-02-02

Publish Date

2019-02-01

Page Start

281

Page End

285

Print ISSN

2537-0286

Online ISSN

2537-0294

Link

https://nrmj.journals.ekb.eg/article_227592.html

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https://nrmj.journals.ekb.eg/service?article_code=227592

Order

227,592

Type

Original Article

Type Code

2,265

Publication Type

Journal

Publication Title

Novel Research in Microbiology Journal

Publication Link

https://nrmj.journals.ekb.eg/

MainTitle

In vitro inhibitory potential of two synthesized fatty amides derivatives against some microbial pathogens

Details

Type

Article

Created At

23 Jan 2023