Fungal diseases cause 1.5 million deaths and cause cutaneous infections to billions of people worldwide every year (Vos et al., 2012; GAFFI. 2015).
       Egypt is the highest populated country in the Middle East and North Africa region. Due to the fact that many risk groups of patients exist in Egypt, Egyptians suffer from serious fungal diseases annually. Zaki and Denning, (2017) reported the estimation of the total burden of serious fungal diseases in Egypt and concluded that about 1,649,686 (2%) of Egyptians suffer from serious fungal diseases annually.
       Recurrent vulvovaginal candidiasis (rVVC) (≥4 episodes/year) was estimated to occur in 1,307,766 million (6%) out of 21.8 million women aged 15 – 20 years in Egypt.