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256985

GEMminer: TEXT MINING TOOL FOR GENOME-SCALE METABOLIC MODEL

Article

Last updated: 28 Dec 2024

Subjects

-

Tags

Mathematics and Computer Science

Abstract

Genome-Scale Metabolic Models (GEMs) contain the known chemical reactions in the studied cell or organism. GEMs can be extended to include more biological processes, such as protein translation and secretion. Therefore, GEMs should be integrated with kinetic parameters to couple the metabolic fluxes with the new biological processes. Searching for these kinetics parameters takes a long time. Now millions of scientific papers are available online in the PubMed database. This tremendous amount of current information with text mining approaches creates new opportunities for finding kinetic information that improves GEMs predictions. This paper introduces GEMminer that uses text mining approaches to find this kinetic information based on the user-defined queries and filter keywords. We have validated the accuracy of GEMminer with a manually curated list of GEM papers. Additionally, we have demonstrated that GEMminer can be used to search for kinetic parameters in the protein secretory machinery in yeast, even though there is no available database containing such parameters. These results show that the proposed GEMminer toolbox is a good search tool in PubMed with user-defined queries and filters.

DOI

10.21608/aunj.2022.122233.1002

Keywords

Text Mining, Genome-scale metabolic models, Text mining tool

Authors

First Name

Zainab

Last Name

Ashraf

MiddleName

Mohamed

Affiliation

Mathematics and Computer Science department, Faculty of Science, Assiut University

Email

zainabashraf@sci.au.edu.eg

City

-

Orcid

-

First Name

Yasser

Last Name

Mohamed

MiddleName

Farouq

Affiliation

Department of Electrical Engineering, Faculty of Engineering, Assiut University, Egypt

Email

yasserm@aun.edu.eg

City

-

Orcid

-

First Name

Ibrahim

Last Name

Elsemman

MiddleName

E.

Affiliation

Department of Information system, Faculty of Computers and information, Assiut University

Email

elsemman@aun.edu.eg

City

-

Orcid

-

Volume

51

Article Issue

3

Related Issue

36411

Issue Date

2022-09-01

Receive Date

2022-02-16

Publish Date

2022-09-01

Page Start

358

Page End

373

Print ISSN

2812-5029

Online ISSN

2812-5037

Link

https://aunj.journals.ekb.eg/article_256985.html

Detail API

https://aunj.journals.ekb.eg/service?article_code=256985

Order

256,985

Type

Novel Research Articles

Type Code

2,242

Publication Type

Journal

Publication Title

Assiut University Journal of Multidisciplinary Scientific Research

Publication Link

https://aunj.journals.ekb.eg/

MainTitle

GEMminer: TEXT MINING TOOL FOR GENOME-SCALE METABOLIC MODEL

Details

Type

Article

Created At

23 Jan 2023