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221259

Simple and convenient synthesis of the bladder cancer biomarker: Nicotinuric acid

Article

Last updated: 05 Jan 2025

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Tags

Chemistry

Abstract

The present work describes a simple and convenient synthesis of nicotinoylglycine (nicotinuric acid) and some other aroylglycines such as substituted pyrazoloylglycines starting from their corresponding carboxylic acids. These acids were converted via two different methodologies, into their corresponding acid azides which were reacted with glycine in alkaline medium to give the target aroylglycines in very good yield. The use of the prepared nicotinuric acid as biomarker for early detection of bladder cancer will be the subject of a next publication.

DOI

10.21608/aunj.2018.221259

Keywords

Bladder cancer, biomarkers, aroylglycines, nicotinoylglycine, pyrazol-4-oylglycine

Volume

47

Article Issue

2

Related Issue

31544

Issue Date

2018-12-01

Receive Date

2022-02-22

Publish Date

2018-12-01

Page Start

100

Page End

106

Print ISSN

2812-5029

Online ISSN

2812-5037

Article File

AUNJ_Volume 47_Issue 2_Pages 100-106.pdf

PDF . 458.2kB

Link

https://aunj.journals.ekb.eg/article_221259.html

Detail API

https://aunj.journals.ekb.eg/service?article_code=221259

Order

221,259

Type

Novel Research Articles

Type Code

2,242

Publication Type

Journal

Publication Title

Assiut University Journal of Multidisciplinary Scientific Research

Publication Link

https://aunj.journals.ekb.eg/

MainTitle

Simple and convenient synthesis of the bladder cancer biomarker: Nicotinuric acid

Details

Type

Article

Created At

23 Jan 2023