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221121

EFFECTS OF BRODIFACOUM, ACETYLSALICYLIC ACID AND ITS COMBINATION ON HAEMOSTATIC, HEMATOLOGICAL AND HEPATIC MARKERS OF WILD RAT RATTUS RATTUS

Article

Last updated: 28 Dec 2024

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Tags

Zoology and Entomology

Abstract

Development of resistance in rodents against rodenticides represents a major challenge for rat management strategies in the light of heavy damage and infestation of crop fields.  The aim of this study is to examine the effects of brodifacoum (BDF), acetylsalicylic acid (ASA), and a novel formulation of both anticoagulants on haemostatic and hematological parameters, hepatic redox status and histoarchitecture. Forty eight adult female wild rats (Rattus rattus) were randomly and equally divided into three groups, eight rats each. BDF induced a significant increase in bleeding and prothrombine time, lipid peroxidation (LPO) and decrease in factor VII and IX and hepatic nitric oxide (NO) levels and catalase (CAT) activity, and eosinophils, lymphocytes and monocytes count. Rats in the combination group were characterized by a significant increase in clotting and prothrombin time and ionized calcium (Ca+2) level together with a significant decrease in factors VII, IX and NO levels, platelet count, mean platelet volume, and hepatic CAT activity. ASA was responsible for a significant increase in bleeding time, factor IX level and hepatic CAT activity, and decrease in hepatic NO level. Adverse changes in hepatic histoarchitecture were observed following each of BDF and ASA exposure. The combination of ASA with BDF further aggravated the histopathological lesions of liver more than BDF alone. It was concluded that ASA induced a joint action with BDF especially regarding the haemostatic markers and hepatocellular features.

DOI

10.21608/aunj.2019.221121

Keywords

Brodifacoum, Acetylsalicylic acid, Rattus rattus, hematology, redox status, Liver

Volume

48

Article Issue

2

Related Issue

31538

Issue Date

2019-12-01

Receive Date

2022-02-22

Publish Date

2019-12-01

Page Start

60

Page End

86

Print ISSN

2812-5029

Online ISSN

2812-5037

Article File

AUNJ_Volume 48_Issue 2_Pages 60-86.pdf

PDF . 1.4MB

Link

https://aunj.journals.ekb.eg/article_221121.html

Detail API

https://aunj.journals.ekb.eg/service?article_code=221121

Order

221,121

Type

Novel Research Articles

Type Code

2,242

Publication Type

Journal

Publication Title

Assiut University Journal of Multidisciplinary Scientific Research

Publication Link

https://aunj.journals.ekb.eg/

MainTitle

EFFECTS OF BRODIFACOUM, ACETYLSALICYLIC ACID AND ITS COMBINATION ON HAEMOSTATIC, HEMATOLOGICAL AND HEPATIC MARKERS OF WILD RAT RATTUS RATTUS

Details

Type

Article

Created At

23 Jan 2023