ManageChatDiscover
221113

Samarium- 5-fluorouracil complex induces prominently the anticancer activity of human colon cancer cell line

Article

Last updated: 05 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Chemistry

Abstract

In the present study samarium - 5-fluorouracil (5-FU) complex was prepared to enhance the effectiveness of the 5-FU drug. This complex was characterized by UV/VIS spectrometry high performance liquid chromatography and differential scanning calorimetry. Furthermore, the antitumor effect of the prepared complex was explored on the human colon cancer cell CaCo2 via evaluation of the cytotoxic activity of this complex through trypan blue cell viability. Apoptosis was also assessed through morphological changes, by Annexin V=PI flow cytometric analysis. The results revealed that the trivalent Sm enhance the 5-FU effect against the chemo-resistant colorectal carcinoma cell line.

DOI

10.21608/aunj.2019.221113

Keywords

Samarium 5-Fluorouracil complex, HPLC fluorescence, UV-visible, binding constant, Thermodynamic parameters, Anticancer activity

Volume

48

Article Issue

2

Related Issue

31538

Issue Date

2019-12-01

Receive Date

2022-02-22

Publish Date

2019-12-01

Page Start

51

Page End

59

Print ISSN

2812-5029

Online ISSN

2812-5037

Article File

AUNJ_Volume 48_Issue 2_Pages 51-59.pdf

PDF . 556.1kB

Link

https://aunj.journals.ekb.eg/article_221113.html

Detail API

https://aunj.journals.ekb.eg/service?article_code=221113

Order

221,113

Type

Novel Research Articles

Type Code

2,242

Publication Type

Journal

Publication Title

Assiut University Journal of Multidisciplinary Scientific Research

Publication Link

https://aunj.journals.ekb.eg/

MainTitle

Samarium- 5-fluorouracil complex induces prominently the anticancer activity of human colon cancer cell line

Details

Type

Article

Created At

23 Jan 2023