Nitric oxide is a bioactive signaling molecule involved in plant responses to several environmental stresses. The present investigation was carriedant to evaluate the effectiveness of different application methods of nitric oxide (seed soaking, soil application and foliar spraying) at different concentrations (0.05, 0.1, 0.2, 0.3, 0.4 and 0.5 mM) on growth attributes of three crop plants (faba bean, cowpea and maize) grown under oxygen deficit (200% field capacity (FC)) and water- deficit stresses (70 and 50% FC). The data merely depicted the potential role of sodium nitroprusside, as a source of nitric oxide, on curtailing the deteriorations of both stresses on the three tested plants where the magnitude of crop responsive ranked as faba bean, cowpea and maize, respectively. The studied crops come in agreement that soaking was the influential practical method in application of nitric oxide. Dose- dependent response was attenuated by different crops where generally 0.1 mM was the most effective dose modulating adverse impacts of hypoxia and water- deficit stresses of different plants.