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220871

PROTECTIVE EFFICIENCY OF CURCUMIN AND BONE MARROW MESENCHYMAL STEM CELLS OF NEPHROTOXICITY INDUCED BY BROMATE IN RATS

Article

Last updated: 28 Dec 2024

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Tags

Zoology and Entomology

Abstract

Potassium bromate (KBrO3) is used in many countries in cosmetic and food industries. In this research, we study the possible renoprotective effect of curcumin (CUR) and bone marrow meschenymal stem cells (BM-MSCs) on the actions of KBrO3 in female rats. Thirty two female rats were categorized into four group, the first work as control, the second was exposed to KBrO3 (100 mg/kg/day for 28 days in drinking water), the third and fourth where exposed to KBrO3 like group 2 and co-treated with either CUR (100mg/kg, ip) twice a week or BM-MSCs (2x106, ip for each rat) once a week for 4 weeks, respectively. Kidney function and oxidative stress parameters were measured calorimetrically in plasma. Expression of caspase-3 in kidney by real time PCR was measured by the comparative Ct (2‑ΔΔCt) method. Apoptosis in kidney was evaluated by TUNNEL assay. The results indicated that treatment with KBrO3 caused nephrotoxicity, as evident by the measured renal structural and functional indices and oxidative stress markers in plasma. CUR and BM-MSCs co-treatment significantly abated most of the indices and biomarkers of the renal toxicity caused by KBrO3, suggesting their beneficial effects with the priority of CUR due to their antioxidant effect.

DOI

10.21608/aunj.2020.220871

Volume

49

Article Issue

1

Related Issue

31477

Issue Date

2020-06-01

Receive Date

2022-02-21

Publish Date

2020-06-01

Page Start

1

Page End

19

Print ISSN

2812-5029

Online ISSN

2812-5037

Article File

AUNJ_Volume 49_Issue 1_Pages 1-19.pdf

PDF . 736.2kB

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https://aunj.journals.ekb.eg/article_220871.html

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https://aunj.journals.ekb.eg/service?article_code=220871

Order

220,871

Type

Novel Research Articles

Type Code

2,242

Publication Type

Journal

Publication Title

Assiut University Journal of Multidisciplinary Scientific Research

Publication Link

https://aunj.journals.ekb.eg/

MainTitle

PROTECTIVE EFFICIENCY OF CURCUMIN AND BONE MARROW MESENCHYMAL STEM CELLS OF NEPHROTOXICITY INDUCED BY BROMATE IN RATS

Details

Type

Article

Created At

23 Jan 2023