Rheumatoid arthritis (RA) is a chronic, inflammatory, and progressive autoimmune disease characterized by several articular, extra-articular, and systemic effects. Scientists are looking for treatment with herbs (e.g. Ginger and Curcuma) that have anti-inflammatory and fewer side effects properties than ordinary drugs. In the current study, an empirical autoimmune disease (Collagen Induced Arthritis rat model [CIA]) that shares several RA features was used to investigate the histopathological appraisals in lymph node and spleen of the rats as well as the ameliorative anti-arthritic effect after 25 consecutive days of Ginger and Curcuma oral administration. Fifty males of albino rats (6-7 weeks old) were divided into 5 equal groups. Group I; control, groups II, III, IV, and V were arthritic. The arthritic groups III, IV, and V received Ginger, Curcuma, and Ginger/Curcuma mixture orally, respectively. Lymph nodes (LNs) and spleens were collected, processed for histopathological examination. The H&E staining showed that the LN of groups III and IV had histiocytic infiltrates replacing the monocytoid-like cells in group II. Group V showed restoration of the normal LN architecture. The spleen sections showed normal cellular components in groups III, IV, and V as opposed to the histiocytes and edema in group II. The reticulin and collagen fibers' content of both the spleen and LN was significantly decreased in group II than group I. On contrary, both herbs increased the reticular and collagen fibers' content significantly; more obviously when they were introduced in combination (i.e. group V). Therefore, our results suggest that the inflammatory ameliorative effect of the combined two herbs is more than any of them alone.