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219958

AMELIORATIVE EFFECT OF THE AQUEOUS EXTRACT OF MUSHROOM (PLEUROTUS OSTREATUS) ON NEUROTOXICITY INDUCED BY CIPROFLOXACIN IN RATS

Article

Last updated: 28 Dec 2024

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Subjects

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Tags

Zoology and Entomology

Abstract

Ciprofloxacin (CPX) is a broad-spectrum antibiotic widely used in both human and veterinary medicine, however, it is misuse causes neurological disorders. In the current study, the protective effects of Mushroom P. ostreatus aqueous extract (MAE) against CPX-induced neurotoxicity have been investigated. Twenty -four adult rats were allocated into four groups, control group, CPX group that received a daily dose of 50 mg/kg for two weeks, MAE group that was supplemented with a daily dose of 200 mg/kg for two weeks and CPX plus MAE group which received CPX (50 mg/kg) for  two weeks then supplemented with MAE (200mg/kg) for another two weeks. The results showed that CPX caused alterations in the levels of acetylcholinesterase (AChE), glutathione (GSH) and lipid peroxidation in the brain tissue accompanied with neurodegenertion in the cerebral cortex and hippocampus in comparison with the control. However, MAE caused alterations in the levels of AChE, total antioxidant capacity and LPO in comparison with CPX group. Brain of rats treated with CPX and supplemented with MAE showed improvement in the parameters of oxidative stress and the histological structure with less neurodegenerative cells in the cerebral cortex and hippocampus.  In conclusion, CPX caused neurotoxicity mediated by oxidative stress and MAE can ameliorate brain tissue against CPX- induced brain toxicity due to its content of antioxidant compound.  

DOI

10.21608/aunj.2021.219958

Keywords

ciprofloxacin, Brain, Rats, Oxidative Stress, Mushroom aqueous extract

Volume

50

Article Issue

1

Related Issue

30978

Issue Date

2021-06-01

Receive Date

2022-02-16

Publish Date

2021-06-01

Page Start

1

Page End

22

Print ISSN

2812-5029

Online ISSN

2812-5037

Article File

AUNJ_Volume 50_Issue 1_Pages 1-22.pdf

PDF . 1.2MB

Link

https://aunj.journals.ekb.eg/article_219958.html

Detail API

https://aunj.journals.ekb.eg/service?article_code=219958

Order

219,958

Type

Novel Research Articles

Type Code

2,242

Publication Type

Journal

Publication Title

Assiut University Journal of Multidisciplinary Scientific Research

Publication Link

https://aunj.journals.ekb.eg/

MainTitle

AMELIORATIVE EFFECT OF THE AQUEOUS EXTRACT OF MUSHROOM (PLEUROTUS OSTREATUS) ON NEUROTOXICITY INDUCED BY CIPROFLOXACIN IN RATS

Details

Type

Article

Created At

23 Jan 2023