Pseudophakic cystoid macular edema (CME) is one of the most significant issues of visual impairment after cataract surgery. Phacoemulsification has significantly reduced the incidence of pseudophakic CME to 0.1%. Optical coherence tomography (OCT) evidence of CME after small incision phacoemulsification is 4%. CME was reported in up to 28% of eyes after pars plana vitrectomy for retained lens fragments and becomes chronic in about 20% of these eyes. The present study aimed to determine the prevalence of CME in cases complicated with dislocated nuclear fragments. Thirty-five eyes of 35 patients were recruited for the study. All cases underwent pars plana vitrectomy (PPV) for dislocated nuclear fragments after complicated phacoemulsification. The outcomes were central foveal thickness, average macular thickness and macular volume measured by optical coherence tomography (OCT) at the 3^rd, the 6^th and 12^th months postoperatively. The results illustrated that eight eyes (22.8%) had CME detected by OCT at the 3^rd months, while only 5 eyes (14.3%) at the 12^th months and only 4 eyes (11.4%) had chronic CME. We concluded that the prevalence of CME is higher in cases complicated with dislocated nuclear fragments than uneventful phacoemulsification.