A 2-year field experiment was conducted at Research Farm of Faculty of Agriculture, Sohag University, Egypt to study the effect of filter mud rates (0, 3, and 6 ton /feddan, fed = 0.42 ha) and NPK fertilizer levels (0. 50, 75 and 100 % of recommended rate) on wheat productivity, NPK uptake, and chemical soil properties. The results showed that levels of NPK had a significant effect on grain number/spike, 1000-grain weight, biological yield, grain yield, grain protein %, NPK uptake, residual NPK, and organic matter in the soil after harvest. Application of 100 % NPK fertilizer level produced the highest quantity and quality of wheat grain and straw yields, in addition to its good effects on soil properties. The used filter mud as organic fertilizer improved the quality of wheat grains and soil properties with no effective increases in wheat yields. The integrated use of filter mud and NPK fertilizer was better than using each fertilizer separately.