Introduction: Control of intraoperative hemorrhage has been one of the principle technical problems in advancing liver surgery. Excess blood loss and intraoperative blood transfusions are associated with increased perioperative mortality and morbidity. Myriads of techniques have been developed to help decreasing intraoperative blood loss thus decreasing morbidity & mortality. Methods: prospective and retrospective study was conducted in Minia university hospital including 20 patients with hepatic lesions who underwent liver resection using CUSA combined with harmonic scalpel from Dec. 2019 to May. 2022. Results: During the study period, 20 patients have under-went liver resections, the mean amount of total operative blood loss was 374 ml (SD 74.9 ml with range 270 ml to 620 ml) and the mean blood loss during parenchymal transection was 132.5 ml (SD 33.3 ml with range 80 ml to 230 ml). The median total operative time was 216 min (SD 40.8 min with range 145 min to 300 min) and the mean parenchymal transection time was 42.5 min (SD 8.95. min with range 25 min to 65 min). The rate of blood transfusions was (5%) and the mean post-operative hospital stay was 5.25 days (SD 2.17 days with range 3 days to 12 days). complications occurred in one case (5%). Conclusion: combined technique of CUSA and harmonic scalpel for liver resection is a safe method for both major and minor liver resections, associated with decreased blood loss, reduced postoperative morbidity, and minimal mortality rates.