Background: Many of the beneficial metabolic effects of bariatric surgery have been ‎attributed to altered peptide hormone profiles, especially involving pancreatic and gut ‎peptides. We aimed to assess the impact of sleeve gastrectomy (SG), one anastomosis ‎gastric bypass (OAGB), and sleeve gastrectomy with loop bipartition (SGLB) on ‎gastrointestinal tract hormones. ‎ Methods: A case series analysis was carried out at our institution from February 2018 to February ‎‎2021. This study included 3 groups subjected to different operations; each group ‎consisted of 50 patients. ‎ Results: This study included 132 women (88%) and 18 men (12%). Mean age in SG, ‎OAGB and SGLB were 33.5 SD3.89, 30.9 SD7.2, and 40.3 SD6.89 respectively. ‎The percentage of change in Peptide YY levels two weeks postoperatively in SG, OAGB, and ‎SGLB were 29.1%, 40.1%, and 65.6% respectively. In Glucagon-like peptide-1 were ‎‎19.3%, 34.1% and 32.8% respectively. However, the percent of change in Ghrelin level ‎two weeks were 36.5%, 50%, and 50.6% respectively. Finally, the percent change in ‎secretin hormone levels were 61.5%, 56.9%, and 46.3% respectively. ‎Conclusions: Differences in gastrointestinal hormones that regulate energy and ‎glucose homeostasis are a possible mechanism for more significant weight loss after SGLB and ‎OAGB compared to SG.‎