Background: Acne vulgaris is a common chronic inflammatory disease of the pilosebaceous unit, characterized by the formation of open and closed comedones, papules, pustules, nodules and cysts. It is the most common disorder treated by the dermatologists. This work aims to evaluate the role of Adapalene in treatment of acne vulgaris. Methods: The study was conducted on 20 patients with acne vulgaris. The age of patients ranged from 16 to 33 years, a 2mm punch biopsy was taken before and after the treatment. Results: Clinical improvement in most of cases which was in the form reduction in the count of acne lesions after 12 weeks of treatment and reduction in the inflammatory infiltrate in the skin biopsies. Conclusion: Adapalene is effective in treatment of acne vulgaris.