Background: Beta thalassemia is a hereditary disorder that results from genetic mutations in the synthesis of beta-globin chains. The imbalance of globin chain synthesis results in aggregates that damage red cell membranes, resulting in intravascular hemolysis. This results in chronic anemia which causes erythroid hyperplasia and extramedullary hematopoiesis. "TDT" patients are liable for several medical complications .liver disease is among the most important of them. This study aims to assess the prevalence of liver disease in children with transfusion-dependent thalassemia at Minia University Hospitals. Methods: This study included 60 children diagnosed with TDT and on deferasirox and another healthy 60 children as control. We assessed ALT, AST, HCV Abs, serum ferritin. Results: Mean ALT (iu/l) was 77.5±54.2, mean AST (iu/l) was 66.3±42.04 and mean serum ferritin (ng/ml) was 4282.5±2612. HCV Abs were positive in 12(20%) of cases. Conclusion: TDT patients at Minia University Hospitals have elevated liver enzymes and 20% of them are HCV positive.