Background: Pancreatic and other upper abdominal organ malignancies can produce intense visceral pain syndromes that are frequently treated with splanchnic nerve neurolysis (SNN) or celiac plexus neurolysis (CPN). Most frequent indication for celiac plexus block is pain secondary to an upper abdominal malignancy, although it is very effective for pain generated by retroperitoneal tumors or metastases. The study aimed to evaluate effect of use a local anesthetic and ethanol for chemical neurolysis to control pain in patients with intra-abdominal malignancy. Methods: prospective randomized single blinded study. It involved Group (A): is formed of 20 patients had splanchnic plexus block with lidocaine 1% and ethanol 75%.  Group (B): is formed of 20 patients used the traditional treatment with analgesics by considering the previous and subsequent consumption of narcotics as a control group. The outcome was measured by the visual analogue scale (VAS) values, quality of life (QOL) opioid consumptions which were evaluated prior to the procedure and at 1 to 2 weeks intervals after the procedure. Any change in pain character and associated constitutional symptoms.  Results: there was statistically significant difference between the pre and post procedure data as visual analogue scale score (VAS) among both groups. Conclusion: local anesthetics and alcohol in splanchnic plexus block was effective than traditional treatment with analgesics in patients with intra-abdominal malignancy.