Background: Coronaviruses causing dangerous diseases for both humans and animals. A new coronavirus was found to be the source of a cluster of pneumonia cases in Wuhan, China's Hubei province, at the end of 2019. The aim of the study is determined various clinical manifestations of COVID-19 in infant and children. Methods: This prospective clinical study was conducted at Minia isolation hospitals and Minia University Hospital of Pediatrics, Minia, Egypt during the period from the first of April, 2020 to 31th of august 2021. 62 children were included in this study aged from 4 months -16 years. Infants and children were diagnosed as Covid-19 positive with real time PCR, then we compare these data between the 1st wave (during 2020) and the 2^nd wave (during 2021). Results: The second wave of 2021 showed significant difference as regarding comorbidities, respiratory symptoms and signs. Conclusion: Children at any age and both sexes are susceptible to COVID-19 virus infection. Conclusion: Children cases in the year 2020, show no or mild clinical manifestations compared with whose admitted during 2021.