Background: In Systemic Lupus Erythrematosis (SLE) patients, recurrent fevers are common. Infection should always be considered and ruled out first. The study objective is to evaluate inflammatory markers in feverish Systemic Lupus Erythematosus (SLE) patients. Methods: 20 feverish Systemic Lupus Erythrematosis (SLE) patients and 20 age and sex matched individuals were served as a control group. According to clinical manifestations of infection, the Systemic Lupus Erythrematosis (SLE) patients were subdivided into infected (group Ι) and noninfected group (group II). All cases were investigated for Complete Blood Count (CBC), neutrophils, Erythrocyte Sedimentation Rate (ESR) and C Reactive Protien (CRP). Results: Neutrophils, Erythrocyte Sedimentation Rate (ESR) and C Reactive Protien (CRP) were found higher in infected Systemic Lupus Erythrematosis (SLE) patients than non infected Systemic Lupus Erythrematosis (SLE) patients. There was a significant difference regarding the presence of infection and neutrophils, Erythrocyte Sedimentation Rate (ESR) 1^st hour and C Reactive Protien (CRP) in infected lupus patients compared to those without infection. Conclusion: Infection is frequent in Systemic Lupus Erythrematosis (SLE) patients. Neutrophils, Erythrocyte Sedimentation Rate (ESR) and C Reactive Protien (CRP) could be used as a tool for early diagnosis of infection in patients with Systemic Lupus Erythrematosis (SLE).