Background: Massive blood loss occurs frequently and remains a challenge in spinal surgery, significant intra and postoperative hemorrhage negatively affects patient outcomes by increasing coagulopathy, postoperative hematoma and anemia. Many efforts have focused on reducing blood loss, Hydrogen peroxide (H₂O₂) is an inexpensive and readily available option with hemostatic and antiseptic properties. The study is aimed to evaluate topical H₂O₂ application on wound in patients undergoing laminectomy. Methods: prospective randomized controlled double blinded study. It involved 80 patients underwent thoraco-lumbar laminectomy. 40 patients received topical H₂O₂ 3% in 100 ml saline (group H), while 40 patients received 100 ml saline wash (group C) as control group. The outcome was measured by postoperative drains, total blood loss and hemoglobin (Hb), hematocrit (Hct) and platelet (PLT) levels after 24 hours and after 48 hours. Results: there was a significant difference in the postoperative blood loss & transfusion and Hb & PLT levels after 48 hours in H₂O₂ group when compared to the control group. Conclusion: H₂O₂ can reduce postoperative blood loss and preserves higher levels of Hb & Hct in a safe and effective manner compared to control group.