Pseudoexfoliation syndrome (PXE) is multifactorial disease genetically related and influenced by age and environmental factors, it is characterized by increase production of an elastic material and its accumulation in the intra and extraocular tissues with increasing risk of cataract. PXE represents an obstacle for surgeons during cataract surgery because of increase the risk of intraoperative and postoperative complications due to weakness of the zonules and poor pupillary dilation. So, this review outlines the approach to patient with PXE and planned for cataract surgery to avoid occurrence of complications.