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237749

Effect of carbon tetra chloride (CCL4) on transforming growth factor -beta (TGF-β) expression in chronic liver disease.

Article

Last updated: 28 Dec 2024

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Subjects

-

Tags

Healthcare research

Abstract

Background: The liver is one of the most important organs in the human body because of its utmost importance, and it plays many essential roles for the body. Carbon tetrachloride affects the body in general and the liver, which sometimes leads to the occurrence of chronic hepatitis and may reach its climax and cause fibrosis. One of the effects of carbon tetrachloride is the stimulation of the beta-TGF pathway. Results: After CCL4 administration; There is highly statistically significant difference in expression level of TGF-β (p < 0.005). Conclusions: This study shows that carbon tetra chloride is promotor for several liver diseases that occur due to activation and upregulation of TGF-β.

DOI

10.21608/mjmr.2021.237749

Keywords

CCl4, TGF-β, Chronic liver disease

Authors

First Name

Omar

Last Name

Tammam

MiddleName

Y.

Affiliation

Department of biochemistry, faculty of pharmacy, Deraya University, Minia, Egypt

Email

-

City

-

Orcid

-

First Name

Mahmoud

Last Name

Elrehany

MiddleName

A.

Affiliation

Department of biochemistry, faculty of pharmacy, Deraya University, Minia, Egypt ** Department of biochemistry, faculty of medicine, Minia University, Minia, Egypt

Email

-

City

-

Orcid

-

First Name

Faten

Last Name

Abo-Aziza

MiddleName

A.M.

Affiliation

Department of Parasitology and Animal Diseases, Veterinary Research Division, National Research Center, Giza, Egypt.

Email

-

City

-

Orcid

-

First Name

Shereen

Last Name

Gaber

MiddleName

S.

Affiliation

Department of biochemistry, faculty of medicine, Minia University, Minia, Egypt

Email

-

City

-

Orcid

-

First Name

Asmaa

Last Name

Bayoumi

MiddleName

M.A.

Affiliation

Department of biochemistry, faculty of pharmacy, Deraya University, Minia, Egypt

Email

-

City

-

Orcid

-

Volume

32

Article Issue

3

Related Issue

34262

Issue Date

2021-07-01

Receive Date

2022-05-17

Publish Date

2021-07-01

Page Start

1

Page End

3

Online ISSN

2682-4558

Article File

MJMR_Volume 32_Issue 3_Pages 1-3.pdf

PDF . 311.2kB

Link

https://mjmr.journals.ekb.eg/article_237749.html

Detail API

https://mjmr.journals.ekb.eg/service?article_code=237749

Order

237,749

Type

Original Article

Type Code

2,212

Publication Type

Journal

Publication Title

Minia Journal of Medical Research

Publication Link

https://mjmr.journals.ekb.eg/

MainTitle

Effect of carbon tetra chloride (CCL4) on transforming growth factor -beta (TGF-β) expression in chronic liver disease.

Details

Type

Article

Created At

23 Jan 2023