Objective: The aim of this study is to highlight the role of MRI with diffusion-weighted images in 
diagnosis of uterine focal lesions especially in differentiation between benign and malignant masses, 
and initial staging of known malignancies. Patients and methods: 34 patients with uterine focal 
lesion were included in the study. The patient's age ranged from 25 to 87 years old with the mean age 
± 49.6 years. All patients were referred from the Obstetrics and Gynecology department to Radio 
diagnosis department AT Al-Azhar Assiut University Hospital during the period from November 
2017 to October 2018. Results: In the current study DW MRI could correctly diagnose 33 lesions out 
of 34 lesions. It correctly diagnosed 22/22 benign lesions (facilitate diffusion) and 11/12 malignant 
lesions, 11 malignant lesion were restricted diffusion; only one malignant lesion show facilitate 
diffuse. Conclusion: the present study suggests that, in addition to conventional MRI features, DW 
imaging provided additional tool for distinguishing uterine benign focal lesions from malignant 
lesions.