Chronic hepatitis C (CHC) is a leading cause of chronic hepatitis, cirrhosis, liver failure,and 
hepatocellular carcinoma world wide. Aim of the Work: Is to evaluate the relation between 
serum eotaxin and carotid intima-media thickness hn obese patients with nonalcoholic fatty 
liver and hepatitis c virus patients. Patient and Methods: This prospective study was carried 
out in department of internal medicine, Minia university hospital,80 persons were studied. 
The study protocol was approved by the institutional ethics committee of school of medicine, 
minia university. Results: The study included 80 subjects subdivided into: Twenty obese 
patients considered as group-1. Twenty patients with chronic hepatitis C virus (without 
treatment by combined interferon and ribavirin); considered as group-2. Twenty patients with 
chronic hepatitis C virus who was treated by combined interferon and ribavirin and had-ve 
pcr for HCV RNA; considered as group-3. Discussion: Hepatitis C virus (Hcv) is a leading 
cause of chronic hepatitis, cirrhosis, liver failure, and hepatocellular carcinoma worldwide.
Conclusion & Recommendation : our study suggests that serum eotaxin level could be a good 
predictor for NAFLD; and response for anti-HCV .treatment. Also, our study recommends 
further studying of serum eotaxin levels and other chemokines, to clarify their role in CHC 
and NAFLD.