Background: Platelet rich plasma (PRP) contains autologous growth factors, which could act 
synergistically with growth factors induced by skin needling in order to enhance the wound-healing 
response. Aim of the study: evaluation of the effect of PRP and microneedling in management of 
post acne scars. Materials and methods: 24 patients with post acne scars attending outpatient clinic 
were offered six sessions of microneedling with PRP on one side and PRP injection on the other side 
of the face at an interval of 2 weeks. Results: 24 patients aged between 18-33 years. Significant 
improvement was observed with the use of combined PRP plus microneedling in the Lt side of the 
face as compared to Rt side which was treated with PRP injection alone. Patients were more satisfied 
with combined microneedling and PRP than PRP injection alone. Conclusion: The clinical results of 
our study showed significant improvement using combination therapy of PRP plus dermaroller and 
the most significant improvement with PRP plus dermapen as compared to PRP injection.