Introduction: Diabetes mellitus type 2 (formerly non-insulin-dependent diabetes mellitus 
(NIDDM) is a metabolic disorder that is characterized by hyperglycemia in the context of 
insulin resistance and relative lack of insulin. Aims of the Work: The aim of the present 
study is the assessment of the plasma level of nesfatin-1 and its association with various metabolic 
parameters in newly diagnosed type 2 diabetic patients. Subjects and Methods: This study 
included 90 Patients were selected from those coming to Minia University hospital diabetes 
and outpatient clinics known to have newly diagnosed Diabetes Mellitus, diagnosed 
according to 2017 American Diabetes association (ADA) criteria. Results: This study was 
conducted on 90 persons selected from our diabetic outpatient clinic and outpatient 
clinic of internal medicine. All subjected were divided into three groups. Discussion: 
Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting 
from defects in insulin secretion, insulin action, or both. (ADA 2013). Conclusion and 
recommendations: The novelty of our study is that we showed, for the first time, 
significantly lower nesfatin-1 levels in diabetic patients (Type 2 DM) but less low in 
prediabetic patients (IGT). Nesfatin-1 is a newly identified polypeptide probably involved, in 
the regulation of food intake. It is important to clarify the relationships between nesfatin-1 
and insulin resistance with regard to diabetes. To elucidate its physiological role further 
studies are required.