Objective: To measure the serum Dickkopf-1 level in neonates with HIE and to study its 
relation to the neurodevelopmental outcome in those neonates in comparison to healthy neonates. 
Methods: We measured serum levels of Dkk-1 by ELISA in neonates with HIE (n = 40) and in 
healthy controls (n = 30). Results: Dkk-1 serum levels increased significantly in HIE neonates than in 
healthy control, Serum DKK-1 levels increased significantly in severe HIE patients. Conclusion: 
DKK1 level was higher in neonates with HIE than normal neonates and DKK1 level correlated 
positively with the degree of HIE.