The objective of the present study is to explore the protective effect of selenium against 
nephrotoxicity induced by aspartame in adult male albino rat. Forty-five adult male albino rats, 
weighting 180 were randomly divided into three groups as follows: first group was given distilled 
water and served as control group; the second group was given aspartame dissolved in distilled water 
in a dose of 500 mg /kg b. wt.; the third group was given both aspartame and selenium. Selenium was 
given at daily dose 0.2 mg/kg dissolved in distilled water and given intra peritoneal followed by 
aspartame with an hour interval for 6 weeks. Serum urea, creatinine were significantly increased in 
rats that had received aspartame also the body was significantly decreased in rats received aspartame. 
Combined Treatment with selenium significantly restored kidney functions, modulate weight 
parameters.