Background: Hypertension is a chronic cardiovascular disease and is very common. Many lifestyle 
and behavioral factors affect the occurrence, exacerbation, and complications of hypertension. 
Hypertensive patient's quality of life is affected by the disease and personal factors like patient 
knowledge and compliance with the treatment regimen. Aim of the study: is to estimate the 
relationship between hypertensive patients quality of life and patient knowledge and compliance to 
management. Subjects and Methods: A sample of 600 hypertensive patients from the internal 
medicine outpatient clinics and the Health insurance clinics in Mallawy general hospital and Rural 
Health Unit of (kalandol) village. The necessary data obtained by A structured interview 
questionnaire, Hill-bone compliance scale and (HRQOL) scale. Results: About 65% of the total 
sample had fair to poor level of compliance. Age, sex, education, employment, income and duration 
of disease affect patients' compliance. On the subject of HRQOL, the highest percentage of the 
hypertensive patients sample had poor scores relating to, role limitation due to physical function, 
social function, and emotional troubles. Conclusion: There is a lack of patient knowledge about 
hypertension. About 65% of the subjects had poor to fair levels of compliance. Age and the disease 
duration affect negatively patients' quality of life. Recommendations: Patient health education about
hypertension. Health promotion programs to enhance compliance of patients with treatment and to 
advance the patient quality of life.