Introduction: Acute coronary syndrome was defined as the cluster of symptoms arising due 
to the rapid drop of blood flow to the heart because of coronary artery obstruction. Aim of the 
work: The aim of this study is to determine. Would the level of prolactin detect early, 
diagnosis of NSTE – ACS??, Would the level of prolactin predict prognosis of NSTE -
ACS??, Would the level of prolactin correlate with grace risk score??. Patients and 
Methods: Our study included 80 patients (Pts.) diagnosed as NSTE-ACS (NSTEMI and 
Unstable angina). The Pts were presented within 3hs from the onset of chest pain to our 
Coronary Care Unit of EL- Minia University hospital in the period from July 2016 to April 
2017. Results: This study included 80 patients (Pts) who presented with NSTE-ACS within 3 
hs from the onset of chest pain, whether un-stable angina or NSTEMI. The Pts were presented 
to our Coronary Care Unit of Minia University hospital in the period from July 2016 to April 
2017. Discussion: Hyper-prolactinemia may reflect neuroendocrine stress reaction to ACS, 
which induces acute endothelial dysfunction, insulin resistance, and Induction of vascular 
immune reactions thus, prolonged hyper-prolactinemia lead to arteriosclerosis, augmentation 
of arterial stiffness, and hypertension. (Medic-Stojanoska et al., 2015). Summary: Our study 
included 80 consecutive Pts, [51 males (63.8%), 29 females (36.2%), with a mean age ± SD 
of 57.42 ± 10.3 years, diagnosed as NSTE-ACS at CCU of EL-Minia University Hospital 
in the period from July 2016 to April 2017.