Introduction: The word enuresis is derived from a Greek word (enourein) that means ―to void urine.‖ 
Enuresis can be divided into primary enuresis (PE) and secondary enuresis (SE). Aim of the Work: 
To detect incidence of nocturnal enuresis and hypercalciuria in patients who has primary nocturnal 
enuresis for better evaluation and management. Patients And Methods: This study included 200 
children, 100 with primary nocturnal enuresis and 100 apparently healthy children serving as controls 
matched in age and sex. Enuretic children were selected from the pediatrics nephrology Clinic and the 
urology clinic at El Minia University Hospital, El Minia. In the period from May to November 2017.
Results: This study was done over the period from May to November 2017 from the pediatrics 
nephrology Clinic and the urology clinic at El Minia University Hospital, El-Minia. Conclusions: (1) 
Ur. Ca/Cr ratio was elevated in nocturnal enuretic patients. (2) Ur. Ca/Cr ratio correlated with 
nocturnal enuresis