Introduction: Hepatic resection remains a challenging surgical procedure due to the risk of major 
bleeding during parenchymal transection compounded by the complex biliary and vascular anatomy 
of the liver. Aim of the study: This study aims to evaluate outcomes of different methods of liver 
resection namely. Clamp crush technique, Ligasure, Harmonic scalpel. Patients and Methods: This 
the study was conducted in Hepatobiliary Surgery Unit in El Minia University Hospital prospectively 
from March 2016 including 30 patients who underwent liver resection as a definite treatment.
Results: From March 2016 (prospectively), thirty patients who underwent liver resection for hepatic 
focal lesions at El Minia University hospital were randomly allocated into three groups (clamp crush, 
harmonic and ligasure group) by means of the sealed envelope, they were prospectively analyzed for 
preoperative data: age, gender, BMI, child-Pugh classification, condition of the liver parenchyma, 
liver functions and planned extent of resection. Conclusion: There are different methods of liver 
transection among of them we used 3 methods in this study each of them has advantages and 
drawbacks.