Introduction: Neonatal jaundice refers to the yellow coloration of the skin and sclera of newborn 
babies that results from the deposition of bilirubin (Woodgate and Jardine, 2015). Aim of the work: 
The aim of this study was to evaluate the efficacy of oral use of fenofibrate, vitamin D and other 
antioxidant vitamins ( E and C) in the treatment of indirect neonatal hyperbilirubinemia. Patient and 
Methods: This Case control study was carried on 80 fullterm neonates suffering from neonatal 
jaundice admitted to the Neonatal Intensive Care Unit in Minia University Hospital and El-Minia 
General Hospital from January 2015 to May 2016. Results: This study included 80 full term (FT) 
neonates admitted to the “NICU" of Minia University Pediatric Hospital and Minia General Hospital 
suffering from neonatal indirect hyperbilirubinemia, from January 2015 till May 2016. The study 
included 80 full term neonates ( 36 - 42wks): (54 males and 26 females), (45 ABO incompatibility, 6 
Rh incompatibility and 29 exaggerated physiological jaundice). These neonates were allocated into 
four groups. The results are shown in tables and figures. Conclusion: In conclusion, addition of single 
oral dose of fenofibrate in jaundiced baby receiving phototherapy in first 24h of treatment can 
significantly reduce the serum bilirubin levels in term newborns and duration of phototherapy .