Introduction: Chronic throat symptoms include hoarseness of voice in the form of aphonia or 
dysphonia, frequent throat clearing, sore throat with pain, burning or irritation, excessive or sticky 
throat mucus, feelings of post nasal drip, nonproductive cough , Globus pharyngeus and cervical 
dysphagia. Aim of the Study: To find if there is benefit of the use of upper Gastro intestinal 
endoscopy in diagnosis of patients with chronic refractory throat symptoms in comparison with 
combined laryngoscope and MSCT of the Neck. Patients and Methods: The current study is a 
Pilot study conducted on: 50 patients suffering from chronic refractory throat symptoms recruited 
from ENT outpatient clinic at minia university hospital from July 2018 to March 2019. Results: This 
study is a pilot study that was conducted in Minia University Hospital at endoscopic unit from July 
2018 to March 2019. Conclusion: Use upper GI endoscopy as an initial investigation in patients with 
refractory throat symptoms with normal laryngoscope and CT finding should be advocated especially 
when the cost of endoscopy is low and high risk of complication as Baretts esophagous or 
complicated GERD.