Introduction: Cirrhosis is the end-stage of most liver diseases. Patients with cirrhosis are at high risk 
of developing bacterial infections, sepsis and sepsis-related death(1)
. Aim of the study: Our aim is to 
evaluate the role of CRP and procalcitonin as a diagnostic tool for detection bacterial infection in a 
hospitalized patients with cirrhosis. Patients & Methods: This study was conducted in Tropical 
medicine department -Minia University Hospitals, from May to October 2018. 90 patients were 
included in the analysis. Forty two patients presented clinically with infection (Group 1), while 48 
patients clinically non infectious (Group 2). Results: Ninty consecutive hospitalized patients with 
liver cirrhosis of different etiologies were included in the study. Forty two patients (61.9% male, age 
61.8±11.2 years) had documented bacterial infection at admission or during the first 3 days of 
admission (Group 1) and 48(66.7% male, age 58.9±8.2 years) were hospitalized for other reasons 
(Group 2). Conclusion: CRP and procalcitonin are good inflammatory markers; CRPis more 
sensitive than procalcitonin in detection bacterial infection but both are specific in detection bacterial 
infection in patients with advanced chronic liver disease.