Introduction: Chronic liver disease is associated with primary and secondary kidney disease and 
impacts markedly on survival (Slack et al., 2010). Aim of The work: The study aimed to compared 
the accuracy of different glomerular filteration rate equations based on creatinine, cystatin C and both 
valuable tools in the detection of kidney disease in hepatitis C virus (HCV)-cirrhosis Egyptian 
patients. Patients and Methods: Study Participants: The study was reviewed and approved by the 
local ethics committee and was conducted in accordance with the Helsinki Declaration. Informed 
consent was obtained from all participants. Results: A total of 60 patients with hepatitis C virus 
(HCV) – related liver cirrhosis who met the inclusion criteria and 30 healthy volunteers as a control 
the group was included in this observational hospital-based, cohort study. Patients and Methods: 
Study Participants: The study was reviewed and approved by the local ethics committee and was 
conducted in accordance with the Helsinki Declaration. Informed consent was obtained from all 
participants. Conclusion: Our study concluded that the most predicting model is CKD-EPI Creatinine 
- Cystatin C (R2=0.785).