Objectives: This study aims to assess the effect of tramadol abuse on sexual functions in males.
Methods: We recruited subjects from Hot Line Clinic of Minia Psychiatric Hospital, Minia during a 
6-month period. After taking their consent, 68 subjects with a history and a positive urine analysis test 
of tramadol abuse were included. They were assessed clinically by international index of erectile 
function (IIEF). They were compared with a control group of 43 subjects with no history of drug 
abuse and negative urine analysis test. Results: All the aspects of sexual function were significantly 
better in the control group than the tramadol abuse group. Within the tramadol abuse group, all the 
parameters of sexual function were significantly better before using tramadol than during tramadol 
use. There was a significant correlation between the number of symptoms and the intercourse 
satisfaction, and erectile function; and between daily dose of tramadol and sexual desire and erectile 
function. Conclusion: Patients with tramadol abuse are more likely to have sexual dysfunctions than 
healthy controls.