Introduction: Diabetes mellitus defines a group of metabolic disorders characterized by 
hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Aim of the work: 
To asses health-related quality of life in a group of diabetic children using different assessment tools.
Patients and Methods: This study included 50 children with Type 1 Diabetes Mellitus who had 
regular follow up in the pediatric Endocrinology outpatient's clinic, Minia University Children's
Hospital. They were recruited during the period from July 2018 to December 2018.They were 
classified into two groups: Group I: included 50 children who had already been diagnosed as 
diabetic patients according to standard American Diabetes Association criteria. Group II: included 50 
apparently healthy children, their ages and sex were matched to the diseased group. They were 
siblings of the diseased groups to be under the same familial circumstances of the patients' group.
Results: Children with diabetes reported significant lower scores (HRQol) in compare with health 
children. Discussion: children with T1DM had lower total generic Qol than controls.
Recommendation: Based on the current study we recommend: Quality of life for children with 
T1DM must be a priority in our treatment modalities in Egypt.