Background: Non-alcoholic fatty liver disease (NAFLD) it is one of the most common causes of 
liver disease worldwide. Visfatin is an adipocytokine hormone, which exerts an insulin-like effect by 
binding to the insulin receptor-1, we aim to investigate the correlation between serum Visfatin and 
NAFLD in Simple obese children. Methods: This prospective study included 62 children clinically 
evaluated as obese and 35 apparently healthy children, age and sex-matched as controls. Patients were 
recruited from the pediatric department of EL-Mina University, children's hospital. While controls 
were collected from healthy school children between September, 2016 and October, 2017. Fasting 
Visfatin, glucose, hemoglobinA1cand lipid levels were assayed and abdominal ultrasonography was 
done for detection of NAFLD. Results: There was a statistically significant correlation between 
serum Visfatin level and BMI (p<0.01), cholesterol levels (p< 0.01), triglycerides levels (p< 0.01), 
LDL levels (p< 0.01), HDL levels (p< 0.01) in both overweight and obese groups. Conclusions: 
Visfatin plays an important role in the pathogenesis of NAFLD.