This study aimed to identify histopathological variables that might contribute to survival, 
mortality of patients, and serious complications after pancreaticoduodenectomy. Patients and 
methods: This is prospective hospital based study that been done on all patients who 
underwent pancreaticoduodenectomy in National Liver Institute and Minia university hospital. 
between the first of January 2015 till the end of December 2016. in the surgical department, 
National Liver Institute, Menoufiya University, and Minia university hospital. Results: We 
found that perineural infiltration and lymphovascular invasion were independently significant 
in multivariate analysis, the effects of combining them in terms of predicting long-term survival 
is very important. Smaller and well-differentiated tumors were associated with significantly 
better patient survival (P < 0.03 and P < 0.01, respectively). Positive lymph nodes were 
associated with reduced survival (P < 0.003). Conclusion: The analyze the histopathological 
parameters influencing long-term patient survival after pancreaticoduodenectomy focusing on 
perineural infiltration and lymphovascular invasion as predictors of long-term survival.