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221719

Change of estrogen receptor, progesterone receptor, and Ki67 after neoadjuvant chemotherapy in patients with locally advanced breast cancer

Article

Last updated: 28 Dec 2024

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Tags

Healthcare research

Abstract

Purpose: The aim of this study is aimed to demonstrate the changes in the estrogen receptor 
(ER), progesterone receptor (PR), Ki-67, after neoadjuvant chemotherapy in the patients with 
locally advanced breast cancer. Materials and Methods: seventy patients who diagnosed 
with locally advanced breast cancer and treated with neoadjuvant chemotherapy. Ki-67, ER, 
PR, tested by immunohistochemistry (IHC) was evaluated before and after neoadjuvant 
chemotherapy. Results: There was a statistically significant reduction in Ki-67, but no 
statistically significant reduction in ER, PR, after neoadjuvant chemotherapy. Conclusion: 
The significant change in the Ki-67 proliferation index may suggest the reduced proliferative 
activity of malignant cells with neoadjuvant chemotherapy.

DOI

10.21608/mjmr.2022.221719

Keywords

estrogen receptor, Progesterone receptor, Neoadjuvant chemotherapy

Authors

First Name

Nada

Last Name

Sholkamy

MiddleName

H. Ali

Affiliation

Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicin, Minia University

Email

-

City

-

Orcid

-

First Name

Wafaa

Last Name

Abd El-Latif

MiddleName

M.

Affiliation

Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicin, Minia University.

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Hassan

MiddleName

A.

Affiliation

Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicin, Cairo University.

Email

yehia_mohmed@gmail.com

City

-

Orcid

-

First Name

Amani

Last Name

Guirguis

MiddleName

S.

Affiliation

Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicin, Minia University.

Email

-

City

-

Orcid

-

First Name

Marian

Last Name

Kamal

MiddleName

F.

Affiliation

Department of Pathology, Faculty of Medicin , Minia University

Email

-

City

-

Orcid

-

Volume

30

Article Issue

4

Related Issue

31649

Issue Date

2019-10-01

Receive Date

2022-02-24

Publish Date

2019-10-01

Page Start

217

Page End

225

Online ISSN

2682-4558

Article File

MJMR_Volume 30_Issue 4_Pages 217-225.pdf

PDF . 404.3kB

Link

https://mjmr.journals.ekb.eg/article_221719.html

Detail API

https://mjmr.journals.ekb.eg/service?article_code=221719

Order

35

Type

Original Article

Type Code

2,212

Publication Type

Journal

Publication Title

Minia Journal of Medical Research

Publication Link

https://mjmr.journals.ekb.eg/

MainTitle

Change of estrogen receptor, progesterone receptor, and Ki67 after neoadjuvant chemotherapy in patients with locally advanced breast cancer

Details

Type

Article

Created At

23 Jan 2023