Introduction: Hepatitis C virus (HCV) infection is one of the most serious global health problems. 
The incidence of HCV infection is increasing, with over 185 million people infected worldwide. Aim 
of the work: The aim of the study was to evaluate the serological rate of Helicobacter. 
ylori (H. pylori) infection in HCV related liver cirrhotic patients, determine its role in upper 
gastrointestinal bleeding whether variceal or not and demonstrate its role in progression of liver 
disease. Subjects And Methods: The current study is a Prospective cross sectional study conducted 
on: Group I: 100 patients of post hepatitis C liver cirrhosis presented with upper gastrointestinal 
bleeding. Age ranges between 40 to 83 years old; 56 male and 44 females, recruited from internal 
medicine department at Minia university hospital from march 2018 to december 2018. Results: 
Demographic data of the patients: The present study was conducted in Minia University hospital at 
endoscopic unit from march 2018 to December 2018. On 100 patients of post hepatitis C liver 
cirrhosis. Age ranges between 40 to 83 years old; (56 male and 44 females) Also, this study included 
50 patients (28 male and 22 females) healthy subjects as a control group. Summary: The aim of the 
study was to evaluate the serological rate of Helicobacter pylori (H. pylori) infection in HCV related 
liver cirrhotic patients ,determine its role in upper gastrointestinal bleeding whether variceal or not,
and demonastrate its role in progression of liver disease.