Background: Preeclampsia has remained a public health threat in both developed and 
developing countries contributing to maternal and perinatal morbidity and mortality globally, 
Kidney injury with proteinuria is a characteristic feature of preeclampsia, yet the nature of 
injury in specific regions of the nephron is incompletely understood Aim and objectives: The 
aim of the present study is to evaluate the role of kidney injury molecule-1 as a biomarker for 
predicting kidney injury in preeclampsia, Subjects and methods: This is a case control study 
was carried out at the department of obstetrics and gynecology, Minia maternity university 
hospital during the period from September 2018 to March 2019, the study was conducted 
on 90 patients were be enrolled in to the study and divided into two groups, Results: the 
results of the study revealed that there is high significant correlation between kidney injury 
molecule -1and severity of preeclampsia, Conclusion: there is an increase in the urinary level 
of kidney injury molecule-1 in PE, implicating their possible value as biomarkers of kidney 
injury,