Introduction: The most commonly used technique for detecting endometrial disease in women with 
AUB is 2D and 3D transvaginal ultrasound. The aim of the work: is to measure endometrial 
thickness, volume, RI and PI in women with peri-\postmenopausal bleeding and correlate it with 
histopathological results to discriminate between benign and malignant endometrial lesions. Patients 
and methods: This study is a controlled clinical trial that was conducted in El-Minia University 
Maternity Hospital, Egypt. Cases were collected from the outpatient clinic and inpatient 
gynecological department and 132 pre-&postmenopausal women were included in this study. All 
cases presented by AUB. The study was conducted between August 2017 and August 2019.The study 
was approved by the hospital ethical committee. The aim of this work is to measure endometrial
thickness, volume ,RI and PI in women with peri-\postmenopausal bleeding and correlate it with 
histopathological results to discriminate between benign and malignant endometrial lesions. Results:
In our study by comparing the AUCs of ET is 0.859 ,EV is 0.875 , PI is 0.902 and RI is 0.930, the 
best variable to predict malignancy is RI followed by PI followed by EV and lastly ET. Conclusion:
3D ultrasonography and Doppler, especially RI, may be useful for discrimination between benign and 
malignant endometrium in women with AUB.