Introduction: One of the most frustrating problems in IVF today is the low pregnancy rate in women 
with poor ovarian response (Webb et al., 2016). Poor responders are estimated to comprise 
approximately 9-24% of IVF/ICSI patients (Papathanasiou et al., 2016). Aim of the Work: The aim 
of our study is to compare the efficacy of a mild ovarian stimulation strategy versus a conventional 
ovarian stimulation in women with poor ovarian response undergoing ICSI. Patients and Methods: 
This study conducted at the Nile Infertility Centre during the period between January 2018 and 
February 2019.The trial protocol was approved by the Ethical Committee of the department of 
Obstetrics & Gynecology, Minia University (approval no. MUEOB0016). Results: Our study was 
carried at Nile Infertility Center during the period between January 2018 and February 2019.The study 
included a total of 170 infertile women with an indication for ICSI and characterized as poor 
responsders according to the Bologna criteria. In conclusion, Mild ovarian stimulation reduce 
patients‟ burden of frequent injections, in terms of embryo quality, pregnancy rate, and cost mild 
ovarian stimulation is a promising alternative to conventional ovarian stimulation for poor ovarian 
responders.